Portrazza dosing and administration

Recommended dose and schedule1

Recommended dose and schedule chart
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  • Premedication1
  • For patients who have experienced a previous grade 1 or 2 infusion-related reaction (IRR), premedicate with diphenhydramine hydrochloride (or equivalent) prior to all subsequent Portrazza infusions
  • For patients who have experienced a second grade 1 or 2 occurrence of IRR, premedicate for all subsequent infusions, with diphenhydramine hydrochloride (or equivalent), acetaminophen (or equivalent), and dexamethasone (or equivalent) prior to each Portrazza infusion

See gemcitabine and cisplatin prescribing information for recommended premedications.

IV=intravenous.

Reference: 1. Portrazza (necitumumab) [package insert]. Indianapolis, IN: Eli Lilly and Company; 2015.